CBD topicals in the form of balms and lotions are primarily designed to target cannabinoid receptors within the layers of the skin rather than enter the bloodstream. However, when large amounts of CBD are applied to the skin it can enter the blood regardless.

Thorough studies on the bioavailability of topical CBD are few, but many people do report excellent results for localised issues.

The best way to absorb CBD through the skin for non-localised issues is with transdermal CBD patches.